Biochem/physiol Actions

Cell permeable: no

Reversible: no

Kd = 6 pM in binding to calmodulin

Product does not compete with ATP.

Primary TargetCalmodulin

General description

A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (K_d = 6 pM).

A 17-residue peptide based on the calmodulin-binding domain of myosin light chain kinase (MLCK). Binds to calmodulin with high affinity (K_d = 6 pM). Inhibits calmodulin activation of MLCK-catalyzed phosphorylation of smooth muscle regulatory light chain(MLC).

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Torok,K., et al. 1998. Biochemistry 37, 6188.Török, K., and Trentham, D.R. 1994. Biochemistry33, 12807.

Packaging

500 µg in Plastic ampoule

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

Ac-Arg-Arg-Lys-Trp-Gln-Lys-Thr-Gly-His-Ala-Val-Arg-Ala-Ile-Gly-Arg-Leu-NH₂

Warning

Toxicity: Standard Handling (A)